منابع مشابه
Reaction of carcinogens with acridine.
Only a very small number of the known substances is strongly carcinogenic. This indicates that carcinogenicity is linked to different qualities which all must be present to produce cancer. The various chemical reactions or qualities brought into relation with carcinogenicity reflect one or more of these factors. None of them seems to comprise all involved parameters. At the same time, none of t...
متن کاملMicrowave-assisted Synthesis of Acridine-1,8(2H,5H)-diones via a One-pot, Three Component Reaction
A new and improved protocol for the synthesis, in good to excellent yields, of acridine-1,8(2H,5H)-diones is described, involving a one-pot, three component reaction of dimedone, arylglyoxals, and ammonium acetate in water under microwave irradiation.
متن کاملREACTION OF QUINONEIMINES WITH KETENES
The reactivity of quinoneimines towards ketene and diphenylketene was examined. N-Phenylbenzoquinoneirnines (I), (2) and also N-phenylnaphthoquinoneimine react with ketene to give the spiro-adducts (5), (7) and (1 1) respectively. These adducts were stable even after prolonged heating in high boiling solvent. Reaction of the above imines with diphenylketene also afforded 13- lactam spiro-a...
متن کاملAssaying potential carcinogens with Drosophila.
Drosophila offers many advantages for the detection of mutagenic activity of carcinogenic agents. It provides the quickest assay system for detecting mutations in animals today. Its generation time is short, and Drosophila is cheap and easy to breed in large numbers. The simple genetic testing methods give unequivocal answers about the whole spectrum of relevant genetic damage. A comparison of ...
متن کاملInduction of neoplasms in planarians with carcinogens.
Studies on the effects of carcinogens in inverte brates have been few and difficult to interpret. Owens et al. (4) have shown that several carcino gens are capable of stimulating growth and regen eration of Euplanaria dorotocephala. However, no abnormalities of growth were reported by these investigators. The pitfalls involved for biologists studying tumors in the invertebrates are pointed out ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1961
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.47.9.1397